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1

Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial

Lipton, Jeffrey H, Chuah, Charles, Guerci-Bresler, Agnès, Rosti, Gianantonio, Simpson, David, Assouline, Sarit, Etienne, Gabriel, Nicolini, Franck E, le Coutre, Philipp, Clark, Richard E, Stenke, Leif

Journal:

The Lancet Oncology

Year:

2016

Language:

english

File:

PDF, 310 KB

english, 2016

2

Overall survival with ponatinib versus allogeneic stem cell transplantation in Philadelphia chromosome-positive leukemias with the T315I mutation

Nicolini, Franck E., Basak, Grzegorz W., Kim, Dong-Wook, Olavarria, Eduardo, Pinilla-Ibarz, Javier, Apperley, Jane F., Hughes, Timothy, Niederwieser, Dietger, Mauro, Michael J., Chuah, Charles, Hochha

Journal:

Year:

2017

Language:

english

File:

PDF, 209 KB

english, 2017

3

An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia

Bajaj, Jeevisha, Hamilton, Michael, Shima, Yutaka, Chambers, Kendall, Spinler, Kyle, Van Nostrand, Eric L., Yee, Brian A., Blue, Steven M., Chen, Michael, Rizzeri, David, Chuah, Charles, Oehler, Vivia

Journal:

Year:

2020

File:

PDF, 10.05 MB

2020

4

Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers

Stephen Yip, Yaron S Butterfield, Olena Morozova, Suganthi Chittaranjan, Michael D Blough, Jianghong An, Inanc Birol, Charles Chesnelong, Readman Chiu, Eric Chuah, Richard Corbett, Rod Docking, Marlo

Journal:

The Journal of Pathology

Year:

2012

Language:

english

File:

PDF, 5.87 MB

english, 2012

5

Chronic myeloid leukemia in Asia

Wing Y. Au, Priscilla B. Caguioa, Charles Chuah, Szu Chun Hsu, Saengsuree Jootar, Dong-Wook Kim, Il-Young Kweon, William M. O’Neil, Tapan K. Saikia, Jianxiang Wang

Journal:

International Journal of Hematology

Year:

2009

Language:

english

File:

PDF, 229 KB

english, 2009

6

Dual inhibition of ras and bcr-abl signalling pathways in chronic myeloid leukaemia: a phase I/II study in patients in complete haematological remission

Jiri Pavlu, Catharina Andreasson, Charles Chuah, Jaspal Kaeda, John M. Goldman, Jane F. Apperley, David Marin

Journal:

British Journal of Haematology

Year:

2007

Language:

english

File:

PDF, 454 KB

english, 2007

7

Imatinib does not impair gonadal function

Journal:

Leukemia Research

Year:

2012

Language:

english

File:

PDF, 115 KB

english, 2012

8

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

Ng, King Pan, Hillmer, Axel M, Chuah, Charles T H, Juan, Wen Chun, Ko, Tun Kiat, Teo, Audrey S M, Ariyaratne, Pramila N, Takahashi, Naoto, Sawada, Kenichi, Fei, Yao

Journal:

Nature Medicine

Year:

2012

Language:

english

File:

PDF, 1.11 MB

english, 2012

9

Resistance to imatinib mesylate in chronic myeloid leukaemia

Junia V. Melo, Charles Chuah

Journal:

Year:

2007

Language:

english

File:

PDF, 416 KB

english, 2007

10

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia

Zimdahl, Bryan, Ito, Takahiro, Blevins, Allen, Bajaj, Jeevisha, Konuma, Takaaki, Weeks, Joi, Koechlein, Claire S, Kwon, Hyog Young, Arami, Omead, Rizzieri, David, Broome, H Elizabeth, Chuah, Charles,

Journal:

Nature Genetics

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

11

A phase I/II clinical trial of autologous cytokine-induced killer cells as adjuvant immunotherapy for acute and chronic myeloid leukemia in clinical remission

Linn, Yeh-Ching, Yong, Hao-Xiang, Niam, Madelaine, Lim, Tsyr-Jong, Chu, Sixian, Choong, Alicia, Chuah, Charles, Goh, Yeow-Tee, Hwang, William, Loh, Yvonne, Ng, Heng-Joo, Suck, Garnet, Chan, Marieta, K

Journal:

Year:

2012

Language:

english

File:

PDF, 227 KB

english, 2012

12

PACE: A Pivotal Phase 2 Trial of Ponatinib in Patients With CML and Ph+ ALL Resistant or Intolerant to Dasatinib or Nilotinib, or With the T315I Mutation

Cortes, Jorge E., Kim, Dong-Wook, Pinilla, Javier, Paquette, Ronald, le Coutre, Philipp D., Chuah, Charles, Nicolini, Franck E., Apperley, Jane F., Jean Khoury, H., Talpaz, Moshe, DiPersio, John F., D

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2013

Language:

english

File:

PDF, 65 KB

english, 2013

13

Reply: The BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with chronic myeloid leukemia

Ong, S Tiong, Chuah, Charles T H, Ko, Tun Kiat, Hillmer, Axel M, Lim, Wan-Teck

Journal:

Nature Medicine

Year:

2014

Language:

english

File:

PDF, 201 KB

english, 2014

14

Successful treatment of NDM-1 Klebsiella pneumoniae bacteraemia in a neutropenic patient

Chien, Jaime Mei Fong, Koh, Tse Hsien, Chan, Kian Sing, Chuah, Thuan Heng Charles, Tan, Thuan Tong

Journal:

Scandinavian Journal of Infectious Diseases

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

15

Final analysis of the efficacy and safety of omacetaxine mepesuccinate in patients with chronic- or accelerated-phase chronic myeloid leukemia: Results with 24 months of follow-up

Cortes, Jorge E., Kantarjian, Hagop M., Rea, Delphine, Wetzler, Meir, Lipton, Jeffrey H., Akard, Luke, Khoury, H. Jean, Michallet, Mauricette, Guerci-Bresler, Agnès, Chuah, Charles, Hellmann, Andrzej,

Journal:

Year:

2015

Language:

english

File:

PDF, 194 KB

english, 2015

16

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia

Kwon, Hyog Young, Bajaj, Jeevisha, Ito, Takahiro, Blevins, Allen, Konuma, Takaaki, Weeks, Joi, Lytle, Nikki K., Koechlein, Claire S., Rizzieri, David, Chuah, Charles, Oehler, Vivian G., Sasik, Roman,

Journal:

Year:

2015

Language:

english

File:

PDF, 3.64 MB

english, 2015

17

Efficacy and safety of dasatinib versus imatinib in the East Asian subpopulation of the DASISION trial of newly diagnosed chronic myeloid leukemia in chronic phase

Chuah, Charles T., Nakamae, Hirohisa, Shen, Zhixiang X., Bradley-Garelik, M. Brigid, Kim, Dong-Wook

Journal:

Leukemia and Lymphoma

Year:

2014

Language:

english

File:

PDF, 974 KB

english, 2014

18

EPIC: A Phase 3 Trial of Ponatinib Compared With Imatinib in CP-CML Patients

Lipton, Jeffrey H., Chuah, Charles, Guerci-Bresler, Agnes, Rosti, Gianantonio, Simpson, David, Lustgarten, Stephanie, Rivera, Victor M., Clackson, Tim, Haluska, Frank G., Baccarani, Michele, Cortes, J

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2015

Language:

english

File:

PDF, 60 KB

english, 2015

19

Ponatinib in Heavily Pretreated Leukemia: 3-Year PACE Trial Results

Cortes, Jorge E., Kim, Dong-Wook, Pinilla-Ibarz, Javier, le Coutre, Philipp D., Paquette, Ronald, Chuah, Charles, Nicolini, Franck E., Apperley, Jane F., Khoury, H Jean, Talpaz, Moshe, DeAngelo, Danie

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2015

Language:

english

File:

PDF, 103 KB

english, 2015

20

Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia

Sun, Wen Tian, Xiang, Wei, Ng, Bee Ling, Asari, Kartini, Bunte, Ralph M., Casey, Patrick J., Wang, Mei, Chuah, Charles

Journal:

Experimental Hematology

Year:

2015

Language:

english

File:

PDF, 1.66 MB

english, 2015

21

The pattern of diagnosed HIV infection in Australia, 1984–1992

McDonald, Ann M., Crofts, Nick, Blumert, Charles E., Gertig, Dorota M., Patten, John J., Roberts, Martin, Davey, Therese, Mullins, Sue E., Chuah, John C.P., Bailey, Kevin A., Kaldor, John M.

Journal:

Year:

1994

File:

PDF, 527 KB

1994

22

OPTIC-2L: a Superiority Trial of Two Lower Doses of Ponatinib Versus Standard Dose Nilotinib in Second-Line Chronic Phase CML

Lipton, Jeffrey, Hochhaus, Andreas, Carella, Angelo, Severinsen, Marianne, Boekhorst, Peter te, Almeida, Antonio, Chuah, Charles, Havelange, Violaine, Baerlocher, Gabriela, Lustgarten, Stephanie, Fari

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2016

Language:

english

File:

PDF, 250 KB

english, 2016

23

The OPTIC Study: a Multi-Center, Randomized Phase 2 Trial with Response-Based Dose Reduction to Evaluate Three Starting Doses of Ponatinib

Gutierrez, Valentin García, Cortes, Jorge, Deininger, Michael, Baer, Maria, Kota, Vamsi, Akard, Luke, Chuah, Charles, Guerci-Bresler, Agnes, Steegmann, Juan Luis, Hernández Boluda, Juan-Carlos, Lustga

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2016

Language:

english

File:

PDF, 216 KB

english, 2016

24

4-Year Results from the Pivotal Phase 2 PACE Trial: Efficacy and Safety in Heavily Pretreated Leukemia Patients

Cortes, Jorge, Pinilla-Ibarz, Javier, le Coutre, Philipp, Paquette, Ronald, Chuah, Charles, Nicolini, Franck, Apperley, Jane, Khoury, H. Jean, Talpaz, Moshe, Baccarani, Michele, Lustgarten, Stephanie,

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2016

Language:

english

File:

PDF, 73 KB

english, 2016

25

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia

Bajaj, Jeevisha, Konuma, Takaaki, Lytle, Nikki K., Kwon, Hyog Young, Ablack, Jailal N., Cantor, Joseph M., Rizzieri, David, Chuah, Charles, Oehler, Vivian G., Broome, Elizabeth H., Ball, Edward D., va

Journal:

Year:

2016

Language:

english

File:

PDF, 3.90 MB

english, 2016

26

High-throughput genotyping of CRISPR/Cas9-mediated mutants using fluorescent PCR-capillary gel electrophoresis

Ramlee, Muhammad Khairul, Yan, Tingdong, Cheung, Alice M. S., Chuah, Charles T. H., Li, Shang

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.61 MB

english, 2015

27

Clinical risk factors predicting genital fungal infections with sodium–glucose cotransporter 2 inhibitor treatment: The ABCD nationwide dapagliflozin audit

Thong, Ken Yan, Yadagiri, Mahender, Barnes, Dennis Joseph, Morris, David Stuart, Chowdhury, Tahseen Ahmad, Chuah, Ling Ling, Robinson, Anthony Michael, Bain, Stephen Charles, Adamson, Karen Ann, Ryder

Journal:

Primary Care Diabetes

Year:

2017

Language:

english

File:

PDF, 456 KB

english, 2017

28

Phase 1 dose escalation multicenter trial of pracinostat alone and in combination with azacitidine in patients with advanced hematologic malignancies

Abaza, Yasmin M., Kadia, Tapan M., Jabbour, Elias J., Konopleva, Marina Y., Borthakur, Gautam, Ferrajoli, Alessandra, Estrov, Zeev, Wierda, William G., Alfonso, Ana, Chong, Toh Han, Chuah, Charles, Ko

Journal:

Year:

2017

Language:

english

File:

PDF, 332 KB

english, 2017

29

Bosutinib (BOS) vs Imatinib (IM) for Newly Diagnosed Chronic Myeloid Leukemia (CML): Initial Results from the BFORE Trial

Cortes, Jorge, Gambacorti-Passerini, Carlo, Deininger, Michael, Mauro, Michael, Chuah, Charles, Kim, Dong Wook, Reilly, Laurence, Jeynes-Ellis, Alison, Leip, Eric, Bardy-Bouxin, Nathalie, Hochhaus, An

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2017

Language:

english

File:

PDF, 76 KB

english, 2017

30

5-Year Updates from the Pivotal Phase 2 Ponatinib PACE Trial: Efficacy, Safety and Landmark Analysis in Heavily Pretreated Patients with Chronic-Phase Chronic Myeloid Leukemia

Cortes, Jorge E., Kantarjian, Hagop M., Pinilla-Ibarz, Javier, le Coutre, Philipp D., Paquette, Ronald, Chuah, Charles, Nicolini, Franck E., Talpaz, Moshe, Baccarani, Michele, Deininger, Michael W., H

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2017

Language:

english

File:

PDF, 89 KB

english, 2017

31

Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial

Cortes, Jorge E., Kim, Dong-Wook, Pinilla-Ibarz, Javier, le Coutre, Philipp D., Paquette, Ronald, Chuah, Charles, Nicolini, Franck E., Apperley, Jane F., Khoury, H. Jean, Talpaz, Moshe, DeAngelo, Dani

Journal:

Year:

2018

Language:

english

File:

PDF, 1.80 MB

english, 2018

32

BIM deletion polymorphism profiling complements prognostic values of risk scores in imatinib-treated Asian chronic myeloid leukemia patients

Than, Hein, Lye, Weng K., Sng, Colin, Allen, John C., Ong, S. Tiong, Chuah, Charles

Journal:

Leukemia and Lymphoma

Year:

2018

Language:

english

File:

PDF, 810 KB

english, 2018

33

The OPTIC Study: A Multicenter, Randomized, Phase 2 Trial to Evaluate Three Starting Doses of Ponatinib With Response-Based Dose Reduction in Patients with Chronic Phase Chronic Myeloid Leukemia Resistant to Prior Tyrosine Kinase Therapy

Gutierrez, Valentin García, Deininger, Michael W., Baer, Maria R., Kota, Vamsi K., Akard, Luke, Chuah, Charles, Guerci-Bresler, Agnes, Hernández-Boluda, Juan Carlos, Neumann, Frank, Xu, Jing, Cortes,

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2018

Language:

english

File:

PDF, 91 KB

english, 2018

34

The arginase inhibitor Nω−hydroxy−nor−arginine (nor−NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target

Ng, King Pan, Manjeri, Aditi, Lee, Lin Ming, Chan, Zhu En, Tan, Chin Yee, Tan, Qiancheng Darren, Majeed, A'Qilah, Lee, Kian Leong, Chuah, Charles, Suda, Toshio, Ong, S. Tiong, Ahmad, Aamir

Journal:

Year:

2018

Language:

english

File:

PDF, 5.29 MB

english, 2018

35

Bosutinib Versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia: Results From the Randomized BFORE Trial

Cortes, Jorge E., Gambacorti-Passerini, Carlo, Deininger, Michael W., Mauro, Michael J., Chuah, Charles, Kim, Dong-Wook, Dyagil, Irina, Glushko, Nataliia, Milojkovic, Dragana, le Coutre, Philipp, Garc

Journal:

Journal of Clinical Oncology

Year:

2018

File:

PDF, 718 KB

2018

36

Patient-reported outcomes in the phase 3 BFORE trial of bosutinib versus imatinib for newly diagnosed chronic phase chronic myeloid leukemia

Cortes, Jorge E., Gambacorti-Passerini, Carlo, Deininger, Michael W., Mauro, Michael J., Chuah, Charles, Kim, Dong-Wook, Milojkovic, Dragana, le Coutre, Philipp, Garcia-Gutierrez, Valentin, Crescenzo,

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

2019

Language:

english

File:

PDF, 790 KB

english, 2019

37

Results from HARMONY: an open-label, multicentre, 2-arm, phase 1b, dose-finding study assessing the safety and efficacy of the oral combination of ruxolitinib and buparlisib in patients with myelofibrosis

Durrant, Simon T., Nagler, Arnon, Guglielmelli, Paola, Lavie, David, le Coutre, Philipp, Gisslinger, Heinz, Chuah, Charles, Maffioli, Margherita, Bharathy, Savita, Dong, Tuochuan, Wroclawska, Monika,

Journal:

Year:

2019

Language:

english

File:

PDF, 1003 KB

english, 2019

38

Lysosome Inhibition by Mefloquine Preferentially Enhances the Cytotoxic Effects of Tyrosine Kinase Inhibitors in Blast Phase Chronic Myeloid Leukemia

Lam Yi, Hui, Than, Hein, Sng, Colin, Cheong, May Anne, Chuah, Charles, Xiang, Wei

Journal:

Translational Oncology

Year:

2019

Language:

english

File:

PDF, 1.35 MB

english, 2019

39

Targeted treatment of imatinib-resistant chronic myeloid leukemia: Focus on dasatinib

Journal:

OncoTargets and Therapy

Year:

2009

File:

PDF, 209 KB

2009

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